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Factor IX (or even Christmas factor even or Christmas-Eve factor) is one of a serine proteases () of the coagulation system; it belongs to peptidase personal S1. Deficiency of this protein drives hemophilia B.
Physiology
Factor IX is inactive unless activated by factor XIa (of the contact pathway) or even factor VIIa (of the tissue factor pathway). Once activated into factor IXa, it acts by hydrolysing of these arginine-isoleucine bond in factor X to form factor Xa. It takes calcium, membrane phospholipids, and factor VIII as cofactors to do sol.
Genetics
A gene for factor IX is located on the X chromosome (Xq27.1-q27.Ii).
Role in disease
Deficiency of factor IX induces Christmas disease (hemophilia B). All over One c mutations of factor IX develop been described; the select few induce there is no illness, however numbers of lead to a important bleeding disorder.
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